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Form 8-K · Current Report · Filed 2025-10-29

Ionis Pharmaceuticals reports Q3 2025 financial results with increased revenue and guidance

Ionis Pharmaceuticals, Inc. reported strong financial results for Q3 2025, with total revenue of $157 million, representing a 17% increase from Q3 2024. The company achieved significant milestones in its product launches and clinical trials, leading to an increase in its financial guidance for 2025. Non-GAAP operating expenses decreased by $31 million, and the company is projecting higher revenue and better operating performance for the full year.

Filer
Ionis Pharmaceuticals Inc. IONS · NASDAQ
Filed
Accession
0001140361-25-039650
CIK
0000874015
Signal
Low impactHealthcare

Items reported

Item 2.02

Results of Operations and Financial Condition

General Statement
Item 9.01

Financial Statements and Exhibits

Exhibits Furnished

Market reaction

Close before filing

$73.57

Next session

+0.8%

Since filing

-29.6%

Latest close

$51.77

What happened, not what will happen — closing prices around the filing date.

Precedent

Previous filings from IONS reporting the same item, with the next session's move:

About Ionis Pharmaceuticals Inc.

Ionis Pharmaceuticals Inc. is a biotechnology company focused on discovering and developing RNA-targeted therapeutics. The primary mission of Ionis is to harness its expertise in antisense oligonucleotide technology to address complex genetic disorders. Ionis is pioneering in the field of RNA-targeted drug discovery, aiming to treat a wide range of diseases, including neurological, cardiovascular, metabolic, and cancer-related conditions. Notably, the company has a robust pipeline of drugs in various stages of development and partnerships with leading pharmaceutical companies to expand the reach and impact of its therapeutic discoveries. As an innovative entity in the biotechnology sector, Ionis Pharmaceuticals plays a significant role in advancing medical treatments that target the underlying genetic causes of diseases, thereby offering new hope and potential solutions to patients worldwide. Its advancements contribute substantially to the growth and evolution of personalized medicine, emphasizing the importance of genetic research in modern healthcare.

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